TALOS (Three-dimensional, Algorithmically-generated Library of DNA Origami Shapes) is a new, free and open-source, fully autonomous design algorithm for generating arbitrary 3D nanometer-scale structures using DNA.

DNA can be programmed to robustly self-assemble into pre-defined nanoscale structures of nearly arbitrary 2D and 3D shape using the principle of scaffolded DNA origami, invented by Dr. Paul Rothemund in 2006. This website offers an online portal to the TALOS software that automatically converts any polygon mesh file specified using simple Computer-Aided Design into the synthetic DNA sequences that are needed to synthesize the target object. In short, TALOS offers the ability to “print” your 3D nanometer-scale geometry in DNA.

Pre-compiled Executables

  • For Microsoft Windows, download here
  • For Mac OS X, download here

For more information on our approach, please see this accompanying article by Jun, Shepherd, et al., ACS Nano, 2019 and the About page.